Blair is best known for her roles in Legally Blonde, Cruel Intentions, The Sweetest Thing, and Hellboy. She is also the subject of Introducing, Selma Blair, a documentary directed by Rachel Fleit, about Selma's life with Multiple Sclerosis, which was released earlier this month to extraordinary acclaim. In 2017, Blair was named a Person of the Year by Time Magazine for her courageous contributions as a Silence Breaker.